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Diabetes Mellitus is Sweet, Bad and Ugly.

The Honey Disease Diabetes Mellitus.

Alzheimer associate with Diabetes

#1. Definition

Diabetes Mellitus is the conjunction of metabolic disorders with the principal characteristic is the presence of high concentration of glucose in the blood in persistent or chronic, resulting in a defect in the production of Insulin, for the consequence resistance in the action to utilize glucose and elevation in the production.

The presence of dysfunction in the metabolism of lipids, proteins, minerals, and electrolytes.
The main symptoms of Diabetes Mellitus are the excessive production of urine (polyuria) and the weight loss without apparent reason. Many times we take like reference this tree symptoms called the Triad from Diabetes or 3 P’ rule (Polyphagia, Polydipsia, and Polyuria) when they are suspicious of Diabetes Mellitus Type 2 or the presence of Insulin resistance.

Diabetes is associated with the presence of complications in diverse organic system from the body; like lose of the view that is associated with the blind, the kidney compromise that develop insufficiency in cases of dialysis and transplant, the blood vessels compromise that progress in the loss of the limbs (Diabetic vasculopathy)

. In the heart the coronary disease and myocardial acute infarction, the brain compromise and in the intestine. This develops into a diverse complication that limits the life quality of the Diabetic.
The word Diabetes the Greek root (diabetes) protractor. Another Latin found similar to Sifon. Like the reference term characterized for the elimination of big amount of urine (polyuria). This was used in the first century from Arturo de Cappadocia, the Greek doctor.

Diabetes was recognized for the first time around 15000 b.c. in the Egyptian antique, who observed that persons that urinated a lot and lost weight. In the papyri from Ebers found in Egypt are described the symptoms and the treatment from that time.

One diet from four days that include boiling from bones, wheat, grains sand, green pump, and soil was Areteo from Cappadocia, who between the 80 and 138, give this affection the name of Diabetes, that means in greek run though, doing reference to sign more attractive in the exaggerated elimination from water, that attribute to a fail from the kidneys, expressed that the water coming in and out from the diabetic without keeping in the body.

The word Mellitus (latin mel, miel) honey was added by Thomas Willis in 1675 when he tests the urine from a diabetic patient with a flavor of honey (the glucose is waste from the urine).

#2 Epidemiology.

In the year 2015, this time around millions of persons in the world are diabetic it will grow to 370 million in 2030. This disease causes diverse complication and frequent damage in the eyes, heart, kidney, nervous and blood vessels.

The acute complications (hypoglycemia, ketoacidosis, hypoosmolar no ketosis are consequences in the ineffective control of this disease. Where the chronic complication (cardiovascular, nephropathic, neuropathies, microvascular damage) are a consequence in the illness progress.

Between the big risk and more frequent that Diabetes produce is to drive. The treatment with Insulin and oral hypoglycemics that give repercussion in the nervous system that progress in microvascular complication, problems produce visual problem like cataracts or glaucoma, principally in the low levels of sugar or hypoglycemia that provoke dizziness, loss of balance, lack of concentration and discoordination and lose of conscience. The diabetes drivers have a high risk to get accidents.

#3 Types of Diabetes.

The classification from the OMS Health World Organization, are recognized three forms of Diabetes Mellitus: Type 1, Type 2 and Gestational Diabetes (develop in the pregnancy), everyone with different causes and different incidence and the second classification is proposed for the committee of experts from the (ADA) American from Diabetes Association.

Induce from pharmacies or chemical substances (pentamidine, nicotinic acid, glucocorticoids).
According to ADA the Diabetes is classified into four groups.

The Mellitus Type 1 Diabetes, in which exist the total destruction (90%) from the cellulose B, it to attend absolute Insulin deficiency. Represent the 5-10% from the DM.
The Mellitus type 2, generate like consequence one progressive defect in the Insulin secretion with elevation in the peripheral resistance at the same time high in the glucose production. Represent between 90-95% of the D.M.
Gestational Diabetes is diagnostic around the second or the 3er trimester from pregnancy, where many time is transitory and the cure is the delivery.
-Multifactorial Diabetes. Produce for many causes; genetic defect from the B cellules, diverse type diabetes neonatal, genetic defects in the Insulin action. Fibrosis cystic, endocrinopathies; like acromegalia of Cushing syndrome.
Substance (pentamidine, nicotinic acid, glucocorticoid) and infection that affects the Immune system.

#4. Diabetes Mellitus type 1

Called Diabetes Insulin Dependent (DMID), diabetes from beginning juvenile or diabetes infant juvenile. Don’t show production from Insulin such to the cells B from the isolates from Langerhans from the Pancreas. The begging destruction in short places, especially in the young, with the predisposition to acute descompensation from the metabolism called ketoacidosis.

Is more frequent in young persons (for low the 25) years) and effect to close to 4.9 millions of people in the world. with high prevalence in North America, represent 5-10% from the DM.
The origin from the DM1 is the autoimmune destruction from the B cells from Pancreas.

In one 10% from the cases doesn’t found immunity markets called “idiopathic”. This last situation we see in the incidence of DM1 from Africa and Asia.
The DM1 belong diabetes autoimmune very different from the adult, from the epidemiologic and clinical point of view is close to DM2, the origin is autoimmune and the treatment requires Insulin.
This influence is special for the determination of alleles from the genes from the Histocompatibility Mayor Complex (CMH)inside the group from HLA, THE CLASS 1. In the group from the HLA class II, Affect overall various alleges from the loci DR3 and DR4 in the heterozygous DR3/DR4 are especially susceptible to present this disease.

The patients express DR32 also are in risk to develop other autoimmune endocrinopathies and Celiac disease. Nearly one 6% from the patient with Diabetes type 1 show Celiac disease associated. In most of the cases this disease is not recognized because show digestive symptoms, this are lights of mistakenly attributed to the bad control of the Diabetes, to one gastropexy or Diabetic Neuropathic.

The Diabetes and the Celiac share common genetic and the inflammation from the nutritional deficiencies cause for the Celiac disease increase the risk to develop Diabetes Type 2. The persons with such diseases are associated have bad control from the glycemic control and the increase in the risk of complications, like retina damage and in the kidney the mortality.

The diet without gluten, result in strict improve from the symptoms from the Diabetes and has protected effect again the development of complication to long term the manager is only the use of Insulin.

#5. Diabetes Mellitus Type 2

Actually, the important factor in the apparition from the Diabetes Type 2 is with one possible Insulin resistance and intolerance to glucose, with the Obesity with the exaggerate ingestion of meals, the relation from the rapid absorption polysaccharides or the slow consumption and the lack of exercise.

The abdominal Obesity is associated with high grease acid levels, which participate in the Insulin resistance and the damage to the B pancreatic cell. Contrary happened with the Diabetes Type 1, is not identifies auto immunizations process.

In the Langerhans islets, the cells produce hormone-like Insulin and the Glucagon, other pancreatic hormones that increase the glucose in the blood. In the Diabetes Mellitus, the pancreas produces a little Insulin or nothing is when called Diabetes Mellitus type 1 when the cells from the body no respond normally to the Insulin that produces DM Type 2.

This avoids or difficult the entrance from glucose in the cells, increase their levels from blood (hyperglycemia). The chronic Hyperglycemia produces in the Diabetes Mellitus one toxic effect that deteriorates the different organs and systems and develops com and death.                                                                                                                                                                    The Diabetes

Mellitus is one chronic endocrine-metabolic disorder, that affects the function from the organs and systems from the body, the process median wich dispose meals like energic resource for the organism (metabolism), the blood vessel (arteries, veins, and capillaries) and the circulation from the blood, the heart, kidney and the nervous system (brain, retina, skin, and sensibility).

Symptoms to Detect Diabetes.
The symptomatology is derivative from the excess of glucose in the blood. Signs and symptoms more frequent:
Polyuria, Polydipsia, and Polyphagia, lose weigh event eating more. Due to the glucose can not store in the tissues the reason don’t get the Insulin sing; like weakness, blurring vision and to progress to blind.

#6. Treatment.
The treatment is restorer the normal glycemic levels in the Diabetes Type 1 and Diabetes Type 2.
In the Diabetes type 1 and in the Diabetes Gestacional the use of the substitutive of Insulin or analogs for Insulin. In the Diabetes Type 2 the treatment substitutive from Insulin or Analogs (oral hypoglycemics).

How can determine if the treatment is given an adequate result, the test glucoside hemoglobin is required (HbA1COA1C). One person no diabetic has one HBA1c 6%, the treatment should be close the result from the A1 the max possible to the value in the DM1.

One wide study called DDCT shows the good result in the A1c around year reduce o include wipe the presence of traditional complications associated with Diabetes: Insufficiency renal chronic, diabetic retinopathies, neuropathic peripheral, etc.

The good manage from the Diabetes Mellitus in all the variants; is the implementation of educational therapy to the sick person, to get a result in the management from right control of their disease, with modification in the food habits sometimes is necessary. (Diet, physical exercise and pharmaceutical treatment).

I invite you to follow the instructions of your doctor and follow a healthy diet with you don’t put in risk your health. I encourage you to follow my advice with the next post about Diabetic Diet post.
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Types of Diabetes Mellitus

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