Acne Progressing to Sever Type
Acne or vulgar acne is known, as a chronic disease from the skin that involves the pilosebaceous unit (hear follicles and oil gland)characterized by the formation of comedones, papules, pustules nodules, and scars, that appear in the face a de superior trunk.
Acne and principal causes.
The development from the vulgaris acne is common in the puberty. Rosacea is more frequent among adults, which is a similar aspect. The presence of the vulgaris acne in adults of older age can be the condition of a subjacent condition like the pregnancy and another like the ovarian polycystic or in the Cushing Syndrome.
The multifactorial causes and the unknown the how some have acne and others do not, which is partially genetic and the gen existence in the predisposition.
Causes From Acne
Increase in the production of oil and hyperplasia from the oil glands. Abnormal peeling from the keratinocyte. Bacteria Propionibacterium acnes presence. Inflammation. Another cause of the presence of acne. Hormonal dysfunction, like the menstrual cycles in the puberty. Shrink from a follicular channel.
The abnormal spreading from the follicular cells, abnormal vincula cells between the follicle and the water retention in the skin, are mentioned like the important mechanism. Stress impulse triggers the discharge from the suprarenal glands.
Hormonal Factor in the Development.
The center attention in the overproduction of seborrhea with the hormonal liberation it’s the principal cause. The cause of acne is the association with many hormones. Androgens are the principal regulation in the production oil; testosterone, the dihydrotestosterone (DTH) and the dehydroepiandrosterone sulfate (DHEAS).
Progesterone inhibit the 5-alfa reductase, that requires to convert the testosterone in the more potent dihydrotestosterone. Estrogens reduce the size of the sebaceous glands and reduce the production of oil. The Insulin and the factor Insulin type 1 of growing (IGF-1) the insulin stimuli the grow in the sebaceous glands. Adrenocorticotrophic hormone delivers, It converts in proopiomelanocortin in the anterior pituitary, induce lipogenesis in the oil glands.
Melacortines are the product from the proopiomelanocortin and stimuli the sebaceous glands. Hormone adrenocorticotropic stimuli the production of oil. What Food Can Causes Acne? There exist speculation in the relation between the consumption of such kind of meals and the production or got worse acne.
There was thinking that the chocolate, mil, sugar or chemicals substances, can be related with the worst acne situation. Only can relationship in the severity of acne between kids and teenager that ingest a diet rich in fat and sugar.
Some kind individual presents such kind of predisposition when the type of the skin is grease make the situation worse.
Causes of Facial Acne and Distribution.
The presence of oil face type in complexity with the hormonal factors can develop this condition, with the appearance in the face and other areas of the body. there exists obstruction of the hair follicles (compound for the hair follicles and the pilosebaceous unit).
The excess of the production of oil starts around 9 years old that stimuli a high production of adrenal androgens and high levels of peeling from squamous epithelium that recover the interior of the follicles with the abnormal quaternization.
With obstruction from the follicular ostium. First in the microscopic way (microtomed). When the production of oil continues, the follicles it gets wide until it’s visible the basic damage from the acne: the comedown.
The difference of a pimple is when existing the microscopic lesion (microtomed) inflammatory stage. Develop acne when microtomed grow and mature and break the skin show up the lesion in comedown. What causes the skin from the face breaks out.
The obstruction contributes to the super population to the bacteria’s Propionibacterium acnes, which produce tissue inflammation, and the present of immunology cells: lymphocyte TCD4 and neutrophils, which infiltrate the zone and disrupted the follicular wall, produce the follicles content; lipids, cellular content and fund bacterias to the surrounding dermis.
The inflammatory answer is extreme with the delivery from the mediator; cytokines, peptides and other, produce the apparition of the papule. To the mayor, inflammation conduces the formation of pustules and the extension and formation of a cyst. The presence of nodules where exist deep inflammation and compound various hair follicles. This lesion produced skin scars.
The number of people that have acne, especially the teenager, present psychological and social alteration. In some cases, can develop a lack of confidence and can be depressed, because of low esteem and shame.
The treatment from acne depends on the extension e intensity from the disease, the production of scars, the factors from the patient like age, hormonal and skin characteristic. Lastly from the history of the clinic answer to the diversity of treatment, also from the psychology that impacts in the life quality.
In general, the acne can be auto limited in the 60% of the cases and respond to combine therapies plus the topic treatment. In the 40% of the cases, the chronic acne and the severity can be prolonged until for more 12 years. A requirement of permanent treatment. Most of the cases are benefit the oral isotretinoin.
Actually, exist a wide diversity of treatment with drugs or medical procedures that allow to limited or resolved the damage from the skin. The application from one thyme solution can be alternative therapeutic and the use of benzoyl peroxide in the control of acne with bactericide power again the Propionibacterium acnes.
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